While my fastest "short run" was in the Mercedes (think coming off the gas, looking down, and seeing it come below 150, and the ex's fingerprints are in the dash), my most famous (notorious) run was in my father's 1979 Ford pickup back when I was in HS. The summer before, the engine had blown, and he rebuilt it, blued and balanced. That thing SCREAMED. And yeah, I know that Cleveland engines weren't put in Fords as standard equipment since '72, but he checked the numbers, and damned if that wasn't a 351 Cleveland in it.
Gillette, Wyoming, to Farmington, New Mexico. 750 miles, through Cheyenne, Denver, and over Wolf Creek Pass. 9 hours.