I'm sure Hillary thought the same thing when Obama came out of nowhere to take her presidency.
...And those wounds remain unhealed.

It's a somewhat different case than a state or district election though, the national election comes down to coalition and yes, even popular vote, dynamics, while at the state or district level the party has much more of an alignment of interests and players. I expect Waxie will have a lot of say in who gets his seat, I have no idea if she is on his list or not...they can use her to beat that 'War on women' drum, but whether that matters a great deal in his district or not, I don't know.