If you've got the resources to run it - go for it.
Typically you'll not have driver issues with any device built in the last few years ; especially higher end stuff as they're designed with 64bit in mind. If you have older legacy devices or "generic" hardware, check to see if there is a driver available before installing.
When I built my current games machine a couple years back I ended up with Vista 64U on it - which installed (and functioned) smoothly and perfectly. When I upgraded to a SSD and Win7U the install was simple and easy.