You speak of a long-cherished dream of mine.
When stationed in Texas and travelling back from visiting "back east", I used to take longer than necessary by driving the remnants in Missouri.
Pixar's "Cars" resonated with me on so many levels...
........But I wouldn't trade the interstates for when I really need to get someplace. Going to my sister's is faster (if you count early check-in and layovers) by road than by air, thanks be to Ike.