I love South Park, and the Simpsons are alright. I just don't want the thread to be overwhelmed with South Park/Simpson replies.
Personally, I like King of the Hill. I think it would make a great live action sitcom, but would have to be watered down. I heard one of my favorite lines on there yesterday. Hank is talking to the mailman and asks, "Who would want to lick a Bill Clinton stamp? What are they thinking? How about a Dale Earnhardt stamp? I mean the man won 7 Winston Cups."