Don't they have two that hors de combat due to strokes? Ted Kennedy and some other gent?
Senator Tim Johnson (D-South Dakota), who probably won't run for re-election.
But the primitives need to bone up on some history.
During the Johnson administration (1963-1969) and the administration of the Incompetent One (1977-1981), even though the Democrats had a near-two-thirds majority in the Senate (close to, but not quite 67), that still didn't stop filibusters.
It's going to be fun to watch.