For example: The USDA should be relocated to some place deep in America's agricultural heartland.
Rationale: It's actions will be more closely aligned with the people whose livelihoods it regulates.
Possible 2nd order effect: If cases are brought by or against the agency, the locals will be the juries. Also, any judges would be local. That means the nominating president will want nominees who won't alienate that voting bloc.