In my previous position I was in charge of going through resumes, contacting legitimate candidates, and interviewing them. I picked out my top three and set up a time for them to meet with the owner, my boss.
You'd be shocked at the things I saw over the years.
Hand-written resumes - Yes, this is true. It was for a clerical position in a digital office and they submitted a hand-written resume via fax machine.
Misspellings - I'm anal about this. If you misspell a word on a resume, you will NEVER get a job. If you do get a job with it, then it's probably not a job worth having.
Typed resume on a typewriter with written notes in the margins, crossed out words with updated information, and they used a Sharpie to black out their references. Haha!
I would get a hundred resumes per day. If it wasn't pleasing to the eye, I wasn't interested and trashed it. Don't use silly fonts. Times New Roman or Ariel is fine. Getting too fancy is not going to help you out. But definitely use a font that is easy to read and stay away from the ones that look like cursive writing or calligraphy. Keep it simple. Oh, and don't use font smaller than 10. Smaller than that is work for some of us.
People would call or stop by and ask if I had received their resumes. My answer was always, "Yes, and you will hear from me if we're interested in an interview." I said that to everyone, even the ones that were trashed. Bugging people is a good way to not get a call.
There are great suggestions in this thread. I'm glad I won't be out looking again for a very long time.