Anybody with two neurons to rub together can see there are at least nine flashpoints relating to the Islamic world, several of which are bound to blow up if he gets in:
Israel/pan-Islam & Palestinian relations
Syrian/Lebanese issues
Israel/Hezbollah
Iranian nuclear program
Iranian designs on Israel
Iranian desires to interfere with internal Iraqi affairs
Pakistani internal issues affecting who there ends up in control of their nukes
Pakistani frontier control issues vs. touchy sovereignity over Waziristan and impact on Afghan war
Darfur
Nor are the Islamic world issues the only problems ahead, there are Chinese/Tibetan/Indian issues, pirates in the HOA which are beginning to get out of hand (could lead to further Islamic issues but religion isn't at the core of it), several non-Islamic related crises in Africa for which he in particular would be expected to take a special initiative to insert us, an increasingly testy Russia trying its hand at ramping up threats against our easternmost NATO allies and wannabes, and on and on.