There's about four or five that make sense as Government issues: Flood control etc., limited unemployment insurance benefits, child labor laws (Excepting family-owned businesses, and with room for age-appropriate part-time work as well), and preventing actual brutality toward and abuse of convict labor. I'd also have to say that on balance Social Security is a good thing, if certainly not without warts in both concept and implementation.
Given the failure rate of small businesses vs. their share of the labor market, and the fact that real life at the employee's micro level is entirely different from life as a Sim in the macroeconomic models of theorists, the well-off, and larger businesses on issues like mobility of labor and freedom to contract for your services, it's just unrealistic and self-righteous to claim the individual worker is in a real bargaining position in the labor market, and able to reliably plot a course to a safe retirement, even if they were all smart enough to do that, which of course they aren't...and even smart people get burned through no fault of their own.
There are a couple of others that I can see some valid reason for Federal support or involvement, but not Federal control, like transportation infrastructure maintenance because of its overriding strategic and macroenomic value.