Mine:
Diablo III (if they scrap the DRM) - Diablo? The blood-drenched, magic-slinging, I piss nuclear napalm and collect enough treasure to pay off the US debt Diablo?
With modern graphics and destructable terrain?
You had me at "Diablo."
Mass Effect 3 - The last 2 installments were solid story telling and game play. You cared not only for your character but your crew as well. To not finish the trilogy would be a crime.
SSX - If you played the original SSX Tricky you knew it was fun and engaging even if extreme sports/snowboarding was never your bag. Now the game is being reborn with massive sandbox environments which means, while there are set start-points for your run anything you can board off of is open to you. There will be more than a dozen massive mountain ranges mapped using NASA topography programs. Then they throw in wingsuits, para-sailing, helicopters and whatever else can add to your airtime.
Guild Wars 2 - The original GW presented on-line gaming with a unique business model that the rest of the industry will be foolish to ignore: buy the game, play on-line for free for as long as you want. GW also had some pretty solid graphics and an excellent card-based powers/skill system. The 2nd installment promises significant game play changes while keeping the same brilliant styling.
GTA V - Many critics of the franchise find the protagonists always being involved in criminal practices to be unsettling. It always has fans who are less than mature (despite the games' ESRB rating) that indulge their more juvenile sides. Mores the pity for them because they're missing out on the real depth of the games. Despite this inevitable drawback the games are works or art. The environments where in these epics unfold are as much a star of the story as the humans. Everything is a pointed commentary on the society the game reflects. The billboards, the radio stations, Even passers-by on the streets capture your attention. Then, as brilliant as these worlds are, the main story is powerful enough to assert itself/stand upon these worlds.
Kingdoms of Amalur: Reckoning - Speaking of works of art KoA:R isn't just a game: it's an event. The main story is written by famed fanatasy author R. A. Salvatore and has art direction meant to turn fantasy novel cover art into reality. It also promises an in-depth play system with over 100 hours of play.