I would go so far as to propose a constitutional amendment against them. If your mother/father/sister/brother/uncle/aunt/spouse was in national office (i.e. Representative, Senator, or POTUS), then you are disqualified.
Until we get back to the mindset that elected office is service to the people and not rulership over the people, it might be the only way.
Before we go to that length, might want to consider term limits first.
But yeah -- I've always seen Barbara Bush as a more-recent version of Bess Truman. Bess did not pull punches and did not play games. She was up-front with her revulsion toward the Cesspool known as D.C. to the point that she packed her bags and went back to Independence, MO during her husband's presidency.
Babs didn't quite go that far, but she basically wore the pants in the family.