There is nothing really that can touch me now. I have the full Daedra gear, high enchantments on the weapons/armor/jewelry, a follower with all Daedra gear/high level mage weaponry, my Alchemy is solid, I can smith all heavy armor and sale it for a inflated price due to the craftmanship. The only thing that can slow me down is groups of high level Wizards attacking simulteneously and I have been using Sanguine's Rose to summon Dremora to distract while I get in amongst them with some whirlwind shouts. The Ice Form shout is the best tool you can have for fighting dungeon bosses and other high level enemies.