Interests > Health & Fitness
Coronavirus Events Timeline and InfoDump
SVPete:
http://www.oyageninc.com/wordpress/wp-content/uploads/2020/03/OyaGen-Press-for-03102020.pdf
OyaGen, Inc. announces a compound in development with broad antiviral activity against coronaviruses including SARS-CoV-2
--- Quote ---Rochester, NY (BUSINESS WIRE)
OyaGen, Inc. The company announced today new unpublished results from collaborative research with the National Institute of Allergy and Infectious Diseases’ Integrated Research Facility at Fort Detrick, MD, suggesting strong dose-dependent antiviral activity of its lead compound OYA1 against live SARS-CoV-2, the causative agent for COVID-19, based on in cell culture infectivity studies.
About OYA1. OYA1 has broad-spectrum antiviral activity in laboratory-based assays against the coronaviruses SARS-CoV-2 and MERS-CoV and also is a dual targetspecific antiviral against filoviruses such as Ebola virus. OYA1 was strongly more effective than a positive-control compound, chlorpromazine HCl, at inhibiting SARSCoV-2 from replicating in cell culture. OYA1 had prior FDA approval as an investigational new drug for treating cancer in the 1960s but was abandoned for a lack of efficacy. Studies at that time demonstrated safety in nonhuman primates and human adults when dosed daily or weekly. Side effects may include cardiac toxicity in children when dosed every day.
--- End quote ---
SVPete:
https://www.sciencemag.org/news/2020/03/did-experimental-drug-help-us-coronavirus-patient
Did an experimental drug help a U.S. coronavirus patient?
By Jon Cohen Mar. 13, 2020, 1:30 PM
--- Quote ---The difficulty the medical center faced acquiring a test for its patient received widespread media scrutiny, but her fate largely escaped notice: After her condition declined, the UC Davis doctors secured what’s known as compassionate use permission from the Food and Drug Administration to test an experimental drug on their patient outside of a clinical trial. The drug, remdesivir made by Gilead Sciences, is given by an intravenous drip. Several randomized, placebo controlled trials of remdesivir for COV-19 are now underway in China and the United States and everyone is looking for quick hints on whether the drug works—a new preprint out today on the drug’s use in three COVID-19 patients is raising questions about its ultimate value.
Remdesivir cripples an enzyme called RNA polymerase that is used by many viruses to copy themselves; it does not specifically target SARS-CoV-2, the virus that causes COVID-19. But it worked well in test tube and animal studies of human coronaviruses, cousins of SARS-CoV-2 called severe acute respiratory syndrome and Middle East respiratory syndrome, that cause similar respiratory conditions. ...
George Thompson, an infectious disease specialist at the medical center, was on the team that cared for the California patient and spoke to ScienceInsider about the case. This interview has been edited for clarity and length; additional information added by ScienceInsider is in brackets.
Q: When did the patient start on remdesivir?
A: From diagnosis to therapy, about 36 hours, which is very short for emergency approval of an investigational drug.
Q: How sick was the patient?
A: We thought they were going to pass away.
...
Q: Has the patient been discharged?
A: To protect privacy, let’s just say they are doing well.
--- End quote ---
SVPete:
https://www.jstage.jst.go.jp/article/bst/14/1/14_2020.01047/_pdf/-char/en
Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies
--- Quote ---Summary:
The coronavirus disease 2019 (COVID-19) virus is spreading rapidly, and scientists are endeavoring to discover drugs for its efficacious treatment in China. Chloroquine phosphate, an old drug for treatment of malaria, is shown to have apparent efficacy and acceptable safety against COVID-19 associated pneumonia in multicenter clinical trials conducted in China. The drug is recommended to be included in the next version of the Guidelines for the Prevention, Diagnosis, and Treatment of Pneumonia Caused by COVID-19 issued by the National Health Commission of the People's Republic of China for treatment of COVID-19 infection in larger populations in the future.
--- End quote ---
SVPete:
Because of the Dems' and MSM's (repetitive and redundant, I know) Trump-Has-Done-Nothing narrative, the Trump Campaign has a timeline webpage of Trump Administration actions, https://www.donaldjtrump.com/media/timeline-the-trump-administrations-decisive-actions-to-combat-the-coronavirus/ . They appear to be updating it regularly from Trump's daily briefings. I've rooted through it selectively, DDGed to find supporting government webpages and non-conservative-source news articles, and merged what I chose from that webpage with my timeline above:
China informed WHO of the outbreak in Wuhan of unknown cause: December 31, 2019, https://www.who.int/csr/don/05-january-2020-pneumonia-of-unkown-cause-china/en/
Taiwanese health officials alerted WHO of the infectivity of coronavirus: December 31, 2019, https://dailycaller.com/2020/03/20/who-taiwan-coronavirus-warning/ , https://www.ft.com/content/2a70a02a-644a-11ea-a6cd-df28cc3c6a68
Taiwan started boarding planes arriving from Wuhan, China to screen passengers for symptoms: December 31, 2019, https://jamanetwork.com/journals/jama/fullarticle/2762689
CDC issued a Level 1 travel notice for Wuhan, China: January 6, 2020, https://afludiary.blogspot.com/2020/01/cdc-issues-level-1-watch-travel-notice.html
CDC established a coronavirus incident management system: January 7, 2020, https://www.cdc.gov/vaccines/videos/coronavirus/COVID-19-webinar.pdf
Covid-19 identified to WHO: January 11 and 12, 2020, https://www.who.int/csr/don/12-january-2020-novel-coronavirus-china/en/
China/WHO claims no evidence of human to human transmission of corona virus: January 14, 2020, https://twitter.com/WHO/status/1217043229427761152
--- Quote ---World Health Organization (WHO)
@WHO
Jan 14
Preliminary investigations conducted by the Chinese authorities have found no clear evidence of human-to-human transmission of the novel #coronavirus (2019-nCoV) identified in #Wuhan, #China.
--- End quote ---
The US started screening arriving passengers from China: January 17, 2020, JFK, SFO, LAX https://www.businessinsider.com/new-disease-virus-china-us-airports-screening-cdc-2020-1 ; O'Hare and Hartsfield-Jackson January 22, 2020, https://www.washingtonpost.com/nation/2020/01/21/us-screenings-coronavirus-expanded-airports-atlanta-chicago/
Dr. Fauci announces the National Institutes of Health working developing a vaccine for coronavirus: January 20, 2020, https://www.cnn.com/2020/01/20/health/coronavirus-nih-vaccine-development/index.html
CDC activated its emergency operations center: January 20, 2020, https://emergency.cdc.gov/recentincidents/index.asp?cid=EPR-homepage
Pharmaceuticals company working with US government to develop vaccine: January 22, 2020, Moderna, https://www.cnbc.com/2020/01/22/moderna-is-working-on-a-vaccine-for-chinas-deadly-coronavirus.html
CDC sought “special emergency authorization” from FDA to allow states to use its coronavirus test: January 23, 2020, https://www.reuters.com/article/us-china-health-cdc-idUSKBN1ZM2XS
Wuhan and other cities in Hubei Province shut down travel: January 23, 2020, https://news.cgtn.com/news/2020-01-27/5-million-people-left-Wuhan-before-the-lockdown-where-did-they-go--NACCu9wItW/index.html
White House announced the formation of the Coronavirus Task Force: January 29, 2020, https://thehill.com/policy/healthcare/480627-white-house-announces-task-force-to-monitor-coronavirus
US personnel evacuated from Wuhan: January 29, 2020 https://abcnews.go.com/US/us-chartering-evacuation-flight-wuhan-coronavirus-zone-california/story?id=68571310
Trump declared a public health emergency: January 31, 2020, https://abcnews.go.com/Health/delta-suspends-us-flights-china-amid-coronavirus/story?id=68666037
State Department raised the travel advisory for China to Level 4, do not travel: January 31, 2020, https://www.usatoday.com/story/travel/2020/01/31/coronavirus-china-flight-ban-delta-cuts-all-flights-white-house/4620989002/
People entering the US from China forbidden: Announced January 31, 2020, effective February 2, 2020, https://www.cnn.com/2020/02/02/us/coronavirus-us-travel-restrictions/index.html This effectively ended flights from and to China, for obvious reasons. The current date for flights to resume is March 30, 2020.
CDC had a team ready to travel to China: February 3, 2020, https://www.reuters.com/article/us-china-health-who-mission-idUSKBN1ZX2BV
HHS, Regeneron Collaborate to Develop 2019-nCoV Treatment: February 4, 2020, https://www.hhs.gov/about/news/2020/02/04/hhs-regeneron-collaborate-to-develop-2019-ncov-treatment.html
Shipping of CDC 2019 coronavirus test kits begins: February 6, 2020, https://www.cdc.gov/media/releases/2020/p0206-coronavirus-diagnostic-test-kits.html
HHS expands partnership with Janssen Research & Development for vaccine development: February 11, 2020, https://www.hhs.gov/about/news/2020/02/11/hhs-janssen-join-forces-on-coronavirus-vaccine.html
HHS to work with Sanofi Pasteur to develop coronavirus vaccine and treatment: February 18, 2020, https://www.statnews.com/2020/02/18/sanofi-announces-it-will-work-with-hhs-to-develop-coronavirus-vaccine/
An NIH clinical trial of Remdesivir begun: February 25, 2020, at University of Nebraska Medical Center, https://www.nih.gov/news-events/news-releases/nih-clinical-trial-remdesivir-treat-covid-19-begins
Experimental vaccine submitted for testing: February 26, 2020, Moderna, https://www.cnn.com/2020/02/25/business/moderna-coronavirus-vaccine/index.html
Testing labs allowed to use tests whose FDA Emergency Use Authorization requests are still pending: February 29, 2020, https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-issues-new-policy-help-expedite-availability-diagnostics
Level 4 travel advisory to Italy, South Korea: February 29, 2020, https://www.usatoday.com/story/travel/2020/02/29/coronavirus-trump-adds-travel-restrictions-italy-south-korea/4914822002/
Iran travel ban announced: February 29, 2020, https://www.statnews.com/2020/02/29/trump-administration-expands-coronavirus-travel-ban-to-include-iran/
CDC lifted federal restrictions on coronavirus testing: March 4, 2020, https://www.cdc.gov/coronavirus/2019-nCoV/hcp/clinical-criteria.html
Trump and VP Pence met with health insurance companies and secured commitment to waive co-pays for coronavirus testing: March 10, 2020, https://www.nbcnews.com/video/trump-pence-meet-with-insurance-executives-agree-to-waive-copays-extend-treatment-80407109506
Army signed agreement with Gilead on experimental COVID-19 treatment: March 10, 2020, https://www.militarytimes.com/news/your-military/2020/03/10/army-signs-agreement-with-drug-giant-gilead-on-experimental-covid-19-treatment/
OyaGen, Inc. announced experimental treatment has been studied by National Institute of Allergy and Infectious Diseases: 3/10/2020, http://www.oyageninc.com/wordpress/wp-content/uploads/2020/03/OyaGen-Press-for-03102020.pdf , "OYA1", not yet tested on humans
Trump suspended travel from Europe: March 11, 2020, https://news.yahoo.com/trump-suspends-travel-from-europe-for-30-days-as-coronavirus-cases-continue-to-grow-014314635.html
Eli Lilly announced partnership with research company to develop a treatment/vaccine as part of the DARPA program: March 13, 2020, https://www.msn.com/en-us/finance/companies/eli-lilly-joins-race-to-develop-coronavirus-treatment/ar-BB116BNR
Trump declared National Emergency: March 13, 2020, https://www.msn.com/en-us/news/politics/what-trumps-emergency-declaration-over-coronavirus-means-for-arizona/ar-BB11a6RO
Trump announced public-private partnerships for drive-through testing: March 13, 2020, https://abcnews.go.com/Health/wireStory/trump-announces-public-private-partnership-increase-national-coronavirus-69587547
FDA granted emergency approval for faster coronavirus test: March 13, 2020, https://thehill.com/policy/healthcare/other/487393-fda-grants-emergency-approval-for-faster-coronavirus-test
FDA emergency approval for Thermo-Fisher coronavirus test (within 24 hours of applying): March 13, 2020, https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-issues-emergency-use-authorization-thermo-fisher
Public-private partnerships allowed to open up drive-through testing collection sites: March 13, 2020, https://www.mercurynews.com/2020/03/13/in-declaring-national-emergency-trump-pledges-drive-thru-testing-greater-flexibility-for-doctors/
FDA granted Roche AG an emergency approval for automated coronavirus testing kits: March 13, 2020, https://www.bloomberg.com/news/articles/2020-03-13/roche-gets-clearance-for-coronavirus-test-that-s-10-times-faster
HHS announced funding for development of two rapid diagnostic tests: March 13, 2020, https://www.hhs.gov/about/news/2020/03/13/hhs-funds-development-covid-19-diagnostic-tests.html
European travel ban extended to include the UK and Ireland: March 14, 2020, https://www.politico.com/news/2020/03/14/white-house-adds-uk-ireland-to-travel-ban-129470
Testing begins of Moderna's experimental coronavirus vaccine: March 16, 2020, at Kaiser Permanente Washington Health Research Institute, https://www.kpwashingtonresearch.org/news-and-events/recent-news/news-2020/kaiser-permanente-launches-coronavirus-vaccine-study-seattle
FDA allowing states to authorize use of tests developed by labs in their states: March 16, 2020, https://seekingalpha.com/news/3552325-fda-to-allow-states-to-authorize-coronavirus-tests
Defense Department to give HHS up to 5M respirator masks, 2,000 ventilators: March 17, 2020, https://www.defense.gov/Explore/News/Article/Article/2115200/dod-poised-to-provide-masks-ventilators-labs-to-hhs-for-coronavirus-fight/
HHS to suspended regulation against doctors practicing across state lines: March 18, 2020, https://www.medicaleconomics.com/news/coronavirus-response-doctors-can-now-practice-across-state-lines
Temporary closure of U.S.-Canada border to non-essential traffic: March 18, 2020, https://www.citynews1130.com/2020/03/18/trump-announces-temporary-u-s-canada-border-closure-amid-virus-pandemic/
HUD foreclosures and evictions suspended for a at least 60 days: March 18, 2020, https://www.hud.gov/sites/dfiles/OCHCO/documents/20-04hsgml.pdf
Carnival Cruise Lines ships available for hospital use (non-corona virus patients): March 19, 2020, https://www.mercurynews.com/2020/03/19/cruise-line-offers-up-ships-for-use-as-temporary-hospitals/
State Department global level 4 health advisory, avoid all international travel: March 19, 2020, https://travel.state.gov/content/travel/en/traveladvisories/ea/travel-advisory-alert-global-level-4-health-advisory-issue.html
US Mexico agree to restrict nonessential cross-border traffic: March 20, 2020, https://www.wesh.com/article/us-and-mexico-coordinating-on-plan-to-restrict-travel-across-the-border-1/31794143
Governors remain in command of National Guard, Federals pay 100% of operations cost (all states): March 22, 2020, https://www.thewrap.com/trump-fema-will-pay-100-of-cost-for-national-guard-in-new-york-california-washington/
Army ordered three army hospitals to deploy to New York and Washington: March 24, 2020, https://armyupdate.com/index.php/2020/03/25/army-medical-hospitals-deploying-to-n-y-and-washington-state/
What I have not yet rooted through, selected, and folded into this timeline is this timeline from National Review, which is explosive - thermonuclear, if not Earth-shattering - https://www.nationalreview.com/the-morning-jolt/chinas-devastating-lies/ . It traces the coronavirus outbreak back into early December, documenting what Chinese medical and government people knew and when, and what and when China told the world.
J P Sousa:
That is a lot of work Pete, thanks. :cheersmate:
Navigation
[0] Message Index
[#] Next page
[*] Previous page
Go to full version